Skip to main content

A genetic tracer?

Back in 2009, an Australian study (the largest ever undertaken) on transsexualism was conducted which tried to see if there were genetic links to the condition. The researchers looked specifically at androgen receptor (AR), estrogen receptor (ERB) and aromatase (CYP19) genes for evidence.

The main function of the androgen AR receptor is as a DNA-binding transcription factor that regulates gene expression; however, the androgen receptor has other functions as well. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype.

The study group included 112 male to female transsexuals and 258 non-transsexual males and associations in repeat lengths of the aforementioned genes were examined.

The conclusion found was that the transsexual group showed longer repeat lengths of the AR gene than the non-transsexual group with no association for transsexualism found in the EB or CYP19 genes. No links to the interaction between the three sets of genes and transsexualism were found. Therefore the only link to the condition was the androgen receptor.

The researchers found that the reduced androgen signalling might contribute to a female gender identity in male to female transsexuals. The longer repeat lengths signified a reduced binding ability with a protein co-activator which was responsible for testosterone signalling in the brain.

Females lack the testosterone surge and so their AR gene is not activated. The report concludes that it is possible that the reduced testosterone levels during development could result in incomplete masculinisation and thus a partially or fully feminised brain.



Comments

Popular posts from this blog

looking past cross gender arousal

Jack’s latest Crossdreamers post got me thinking about cross gender arousal and how it could be avoided; also whether it even matters. This with particular focus on the inability to relate of someone on the outside looking in.

You see, sexuality is a very complicated thing to begin with and when you then add gender identity ambiguity it becomes a recipe to really confuse someone.

So imagine that you are a little boy who identifies as a girl but then along comes puberty and short circuits everything by having the sex you identify with also be the sex you are attracted to. For in essence this is what happens to all all male to female gender dysphoric trans persons who are attracted to women.

So I ask myself: can I imagine a scenario where this inherent contradiction would not produce sexual confusion? The answer is that I cannot.

I am in the unique position, like many of you, to have experienced an early identification with the feminine become sexualized later on. This brought confusion…

understanding the erotic component

I have written about crossed wires before in two separate posts. The idea is that one cannot pass through puberty and the development of sexual feelings for females and not have your pre-existing gender dysphoria be impacted through your psychosexual development. The hormone responsible for your libido is testosterone which is present in much stronger concentration in males and is why gynephilics are most likely to experience erotic overtones as the conflict between romantic external feelings and their pull towards the feminine become permanently intertwined.

Because I came from a deeply religious family where sex was not discussed much at all, I grew up with little access to information and was very much ignorant of matters relating to the subject. With no firsthand experience in intercourse until I married I was then faced with the reality that my ability to perform sexually had been deeply impacted by my dysphoric feelings. This began years of turmoil and self-deprecating thoughts …

another coming out

Recently I had lunch with one of the young estimators who occasionally works with me here in Toronto. We were chatting about work and our respective lives when she queried about my love life:

“So how is it going on that front. Meet anyone interesting lately?”

I reflected for a moment and then said:

“My situation is a little particular and if you don’t mind I can share something about myself”

She leaned in a bit and told me to please go ahead.

“I am trans” I said matter of factly.

She looked at me and smiled and said:

“Really? That’s so neat”

She is 35 years old and a lovely person which is why I knew I could confide in her. I then added that I had been reflecting on whether I would switch companies and begin working as Joanna and although she is totally open she also knows how conservative our business can be. So I told her that if I did decide to it would definitely be under a different umbrella.

Then yesterday I was coming back to my place and the lady who rents it to me, who is abo…