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new study on blood clot risk

This is not to scare anyone but it would be one of my primary concerns as an older person potentially beginning HRT...


  1. It's certainly a concern; thank you for bringing it to our attention. Although it's been common knowledge that HRT increases risks for blood clots and strokes I had no idea it was this high. I've forwarded the article to an endocrinologist friend; we'll see what he thinks and advises.

    1. Please let us know what he says Emma

  2. A very close friend (and a blogger still listed on TC) passed away a couple of years ago from a a stroke (blood clot). She had been on a very long motorcycle trip to see a trans friend. The trip was about 7 hours. She got a hotel room, decided to get some rest, and never woke up. She was in her early 50's when she passed away.

    She began HRT in 2007 and had her GRS in late 2008. She was Kaiser member, and may have been part of the study.

    We'll never know if the blood clot was related to HRT but it's clear that more research needs to be done on the effects of HRT on transwomen and, more importantly, safe ways for transwomen to achieve some level of happiness through hormone therapy.

    Thanks for posting this, Joanna. I, for one, was glad to see that studies are being done.

  3. I am going to bring up this study with Dr Morris when I see him next. I have not decided what I am doing yet but understanding all the risks will go a long way towards helping me make up my mind

  4. I'm a little baffled, and actually disheartened, that this is news. I mean, I suppose this study *confirms* the working hypotheses of every doctor I have ever worked with, but it not only comes as no surprise to me, but I have been actively living to avoid such maladies for decades.

    I transitioned in the 1990s. Everyone from my endocrinologist to my primary care doc to my gender therapist talked about exactly these issues with me. Throughout the decades, the research has always become clearer, and I was informed (or kept myself informed) of every new finding as the hypotheses became increasingly obvious. If, in the age of "informed consent," this information has stopped been being doled out while estrogen and progesterone are being doled out like candy (equally unhealthy, now that I think about it), the medical community has failed newer transitioners.

    I have always been told to avoid long airline trips - take multiple stops if traveling far. (It's cheaper anyway, as non-stop flights are in higher demand.)

    I have always been told to take a baby aspirin regimen to reduce the risks of cardiovascular problems.

    I have always been told that exercise and eating properly would be more important for me than your average person.

    I have always been told to watch for the signs of clotting, and to rush myself to the hospital even for false alarms, which I have over the years, several times, and each time, thankfully, it has been a false alarm.

    My estrogen dosage has changed over the years as my doctors, even as I moved many times and lived in many cities across the United States, as has my method of ingesting, as the studies on this topic have been ongoing. As a long-time post-op (SRS/genital reconstruction to be clear) patient, I take the lowest does of estrogen I possibly can, in the form of estradiol, which I take in tablets that dissolve under my tongue.

    I have actively kept myself safe for 20 years with this very information in mind. As I am now in my mid 40s, I take cardiovascular health even more seriously than when I first transitioned. Even through a serious arthritic condition that hit me early in life, and which has been crippling at times, I work through whatever pain I have on the latest low-impact machine technology to exercise regularly.

    HRT can be done safely, I promise you all. It's just that it must - like every other part of transition - be done *mindfully*. If this is new information to you, allow the fear to alert you to danger, not make you afraid of it. It's information. It's power.

    1. ---Your Friendly Neighborhood Caryn Bare

      (dunno why my computer keeps resetting my name LOL)

    2. Caryn this is extremely valuable input from someone who transitioned years ago. I was also aware of the risks but not that they were quite this acute. Of course of one keeps healthy lifestyle one minimizes the chances of contracting a clot. I had a stroke in my mid 40's which Dr Morris duly noted but he said these situations can be mitigated.

    3. Caryn, thank you so much for your comments. It gives me some hope.

      Exercise and eating right has always been a part of my "mental health package" and something I would continue with into HRT and beyond. I'll note that, without going into detail, exercise and eating right were not a part of my dear friend's daily life prior to her passing.

  5. I've already suffered two blood clots without any HRT to hasten them. So, I've known, for quite some time, that I am SOL on the HRT. Still, I feel I have experienced a quite satisfactory transition process. From the blood work that was done after my last DVT clot, I was told by the doctor that my hormone levels were close to average for a woman in her sixties - which is what I am! I'd still like to know what the difference would be if I were fueled by female hormones, but I can live with things the way they are - figuratively and literally.

    1. Happy things are going well Connie 😁


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