There is a caveat however.
While transition may bring you peace it may also being a host of other problems in the form of marriage breakups, estrangement from children, job loss and other challenges which may undo the benefits for you. If we are in middle age these decisions can be extremely difficult as we are typically embroiled with young children and in the middle of careers. This is why very young or much older transitioners tend to have an easier time. Either your life is only just beginning or conversely you are at that stage of life where retirement affords you your peace at long last.
No matter when you decide to do this it will be hard and your mileage may vary depending on your unique circumstances. This is why weighing the potential outcomes becomes crucial.
Life is far from perfect and sometimes making one choice starts a chain reaction we had not anticipated. But if our dysphoria is so extreme as to be debilitating we will do what we must and let the consequences be what they may.